NeoGenomics experiences constructive knowledge for RaDaR liquid biopsy take a look at in head/neck most cancers


NeoGenomics (NASDAQ:NEO) unit Inivata reported constructive knowledge for its RaDaR liquid biopsy take a look at in head and neck squamous cell carcinoma (HNSCC).

Within the LIONESS examine, blood samples taken from 17 sufferers with stage 3-4B, p16-negative HNSCC who obtained curative-intent major surgical therapy had been examined utilizing RaDaR to detect circulating tumor DNA (ctDNA) as proof of minimal residual illness (MRD) and recurrence pre- and post-surgery.

The corporate mentioned all sufferers had detectable ctDNA previous to surgical procedure (100% scientific detection).

In monitoring after surgical procedure, ctDNA was detected in 5 sufferers at low ranges, per earlier research using RaDaR in breast and lung most cancers.

The corporate added that ctDNA was detected previous to development in all 5 sufferers with scientific recurrence, with lead occasions forward of scientific affirmation starting from 108 to 253 days.

Within the remaining 12 sufferers there was no recurrence detected, indicating a 100% scientific specificity of the RaDaR assay and confirming post-operative tumor clearance.

“The assay confirmed exceptionally excessive sensitivity, detecting ctDNA in each HNSCC affected person who went on to recur, which together with its specificity demonstrates the potential of RaDaR to establish HNSCC sufferers at an elevated threat of relapse, enabling earlier intervention and personalised remedy planning,” mentioned Inivata’s Chief Medical Officer David Eberhard.

The info from the Liquid BIOpsy for MiNimal RESidual DiSease Detection in Head and Neck Squamous Cell Carcinoma (LIONESS) examine had been printed within the British Journal of Most cancers.


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